Reconsidering remission in recurrent late-life depression: clinical presentation and phenotypic predictors of relapse following successful antidepressant treatment
A wide range of phenotypic factors differed between remitted LLD and comparison groups. Fewer measures differed between relapsing and sustained remission LLD subgroups, with less social support and greater stress informing vulnerability to subsequent relapse. This research suggests potential targets for relapse prevention and emphasizes the need for clinically translatable relapse biomarkers to inform care.
Authors
- Warren D. Taylor (ORCID: https://orcid.org/0000-0002-9975-3082)
- Damian Elson
- Robert T. Krafty (ORCID: https://orcid.org/0000-0003-1478-6430)
- Sarah M. Szymkowicz (ORCID: https://orcid.org/0000-0001-5333-7211)
- Kyle J. Jennette (ORCID: https://orcid.org/0000-0002-3641-8957)
- Meryl A. Butters (ORCID: https://orcid.org/0000-0002-2563-817X)
- Olusola Ajilore (ORCID: https://orcid.org/0000-0003-0737-0437)
- Carmen Andreescu (ORCID: https://orcid.org/0000-0003-3767-5127)
- K. Scott Baker (ORCID: https://orcid.org/0000-0002-9207-6162)
- Brianca Renfro
- Angie Georgaras
Institutions
- Emory University (US)
- University of Illinois Chicago (US)
- Valley Health System (US)
- Geriatric Research Education and Clinical Center (US)
- University of Pittsburgh Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Psychological Medicine
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1017/s0033291724003246
- Citations
- 4
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 1.79
Funders
- National Institute of Mental Health
- National Center for Advancing Translational Sciences