Whole-Genome Methylation Sequencing Analysis and Functional Verification of LIM-Homeobox Family Genes in Cervical Cancer
In our present work, genome-wide DNA methylation maps of cervical cancer tissues before and after radiotherapy were successfully constructed. We found that LHX5 and LHX9 genes are closely related to cervical cancer. LHX5 and LHX9 have a negative effect on cervical cancer. The migration ability of LHX9 silenced cells was significantly enhanced after irradiation.
Authors
- Qin Yu (ORCID: https://orcid.org/0000-0003-0965-9461)
- Xue Meng (ORCID: https://orcid.org/0000-0001-7571-5500)
- Jing Suo
- Z. G. Deng (ORCID: https://orcid.org/0000-0002-7161-9519)
- Jie Shi (ORCID: https://orcid.org/0000-0001-6072-7031)
- Rong Yu (ORCID: https://orcid.org/0009-0008-0816-9587)
- Hao Yang (ORCID: https://orcid.org/0009-0000-2079-7908)
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- International Journal of General Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/ijgm.s451841
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Natural Science Foundation of Inner Mongolia