Liver Transplant Outcomes of NMP Allografts with End-Perfusion Lactate Greater or Equal to 2.5 mmol/L

Background: Normothermic machine perfusion (NMP) is increasingly used for liver transplantation (LT) to reduce ischemia-reperfusion injury and improve graft outcomes. Allograft lactate clearance thresholds, ranging from < 1.7 mmol/L to 2.5 mmol/L, are commonly used in clinical practice, though their predictive value remains debated. This study aimed to compare LT outcomes based on end- perfusion lactate levels in NMP livers.

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Publication Details

Journal
American Journal of Transplantation
Published
2025-01-01
DOI
https://doi.org/10.1016/j.ajt.2024.12.244
Primary Topic
Organ Transplantation Techniques and Outcomes
Type
article
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article

Liver Transplant Outcomes of NMP Allografts with End-Perfusion Lactate Greater or Equal to 2.5 mmol/L

Caroline C. Jadlowiec, Stephanie Ohara, Kunam S. Reddy, Michelle Nguyen et al.
American Journal of Transplantation
Organ Transplantation Techniques and Outcomes
article

Liver Transplant Outcomes of NMP Allografts with End-Perfusion Lactate Greater or Equal to 2.5 mmol/L

Caroline C. Jadlowiec, Stephanie Ohara, Kunam S. Reddy, Michelle Nguyen, Amit K. Mathur, Xingjie Li
article en

Abstract

Background: Normothermic machine perfusion (NMP) is increasingly used for liver transplantation (LT) to reduce ischemia-reperfusion injury and improve graft outcomes. Allograft lactate clearance thresholds, ranging from < 1.7 mmol/L to 2.5 mmol/L, are commonly used in clinical practice, though their predictive value remains debated. This study aimed to compare LT outcomes based on end- perfusion lactate levels in NMP livers.

American Journal of TransplantationVol. 25(1)
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Organ Transplantation Techniques and Outcomes
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