Tumor‐Selective Nano‐Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll‐Like Receptors (Small 1/2025)
Tumor-Selective Delivery In article number 2406870, Zhi-Yue Zhang and co-workers developed a nano-dispatcher to facilitate tumor-selective co-delivery of a monocarboxylate transporter 4 (MCT4) inhibitor and a TLR7/8 agonist. This approach enhances the immunotherapeutic effect by synergistically regulating lactate metabolism and activating dendritic cells.
Authors
- Yun Guan (ORCID: https://orcid.org/0000-0003-1321-6655)
- Zhang Shi-ying (ORCID: https://orcid.org/0000-0001-5405-7158)
- Xiaoyue Yang (ORCID: https://orcid.org/0000-0002-9331-0512)
- Lingling Huang (ORCID: https://orcid.org/0000-0002-7790-2788)
- Yixuan Guo (ORCID: https://orcid.org/0000-0002-0229-3674)
- Hui Li (ORCID: https://orcid.org/0000-0003-2597-6344)
- Hongfei Chen (ORCID: https://orcid.org/0000-0003-3159-8386)
- Liu Yang (ORCID: https://orcid.org/0000-0002-5966-4923)
- Zhiyue Zhang (ORCID: https://orcid.org/0000-0003-0368-8843)
- Xia Li (ORCID: https://orcid.org/0009-0006-7410-2415)
- Yan‐Yun Hao
- Jing Zou (ORCID: https://orcid.org/0000-0002-4080-0032)
Institutions
- Shandong University (CN)
Publication Details
- Journal
- Small
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/smll.202570005
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00