Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1
CENPM is the key gene that drives ACC metastasis, and a robust biomarker for ACC prognosis. Silencing CENPM impedes ACC metastasis in vitro and in vivo by physical interaction with immune checkpoint ligand FGL1. FGL1 is overexpressed in ACC and promotes ACC metastasis.
Authors
- Jiangping Hou
- Wenxia Su (ORCID: https://orcid.org/0000-0002-2687-596X)
- Zheng Liu (ORCID: https://orcid.org/0000-0001-6952-3406)
- C. X. Lin
- Hao Chen (ORCID: https://orcid.org/0000-0003-0018-480X)
- Yaxin Li (ORCID: https://orcid.org/0000-0002-5871-9806)
- Guojun Gao (ORCID: https://orcid.org/0000-0002-9097-6474)
- Cunru Zou
- Chengyue Liu (ORCID: https://orcid.org/0009-0002-2043-9718)
- Qiupeng Yan
- Yu Zhang (ORCID: https://orcid.org/0009-0009-1389-916X)
Institutions
- Weifang Medical University (CN)
- Second Hospital of Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/ctm2.70182
- Citations
- 5
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 10.03
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province