Clozapine Induces Agranulocytosis via Inflammatory and Hematopoietic Cytokine Induction of the JAK–STAT Signaling Pathway: Evidence From Network Pharmacology and Molecular Docking
Clozapine-induced agranulocytosis may be linked to the JAK-STAT inflammatory signaling pathway through inflammatory and hematopoietic-related cytokines. Our findings enhance our comprehension of the potential mechanisms underlying clozapine-induced agranulocytosis.
Authors
- Ranli Li
- Yun Sun
- Chuanjun Zhuo (ORCID: https://orcid.org/0000-0002-3793-550X)
- Fuqiang Mao (ORCID: https://orcid.org/0000-0002-8826-1058)
- Ying Zhang (ORCID: https://orcid.org/0000-0003-1620-3825)
- Qiuyu Zhang (ORCID: https://orcid.org/0000-0002-4823-5031)
- Lei Yang (ORCID: https://orcid.org/0000-0002-9473-8625)
- Ximing Chen (ORCID: https://orcid.org/0000-0002-9079-2755)
- Yachen Li (ORCID: https://orcid.org/0009-0006-5230-5967)
- Lina Wang (ORCID: https://orcid.org/0000-0002-5323-5431)
Institutions
- Nankai University (CN)
- Tianjin Anding Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/cns.70206
- Citations
- 5
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.89
Funders
- National Natural Science Foundation of China