In vitro antiplasmodiale activity and neurotoxicity of Entandrophragma angolense, Griffonia simplifica, Uapaca guineensis, three traditional plants used against malaria

Malaria remains a global health challenge, with increasing interest in plant-based therapies as potential alternatives to synthetic antimalarial drugs. Entandrophragma angolense, Griffonia simplifica, Uapaca guineensis are traditionally used for malaria treatment in West Africa. While their antimalarial properties have been documented, their potential neurotoxic effects have not been fully investigated. This study evaluates the in vitro antiplasmodial activity and neurotoxicity of extracts from these plants using neuronal cell lines and biochemical assays to assess cell viability. Entandrophragma angolense showed the best antiplasmodial activity. The findings highlight a concentration-dependent effect on neuronal viability, with Griffonia simplifica demonstrating the lowest neurotoxic potential. These results emphasize the need for further investigations to optimize the therapeutic index of these plant-based remedies.