CREB and AKT Levels Higher in Attention Deficit Disorder (ADD) Individuals

Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric neurodevelopmental disorder in children and adolescents. CREB (cAMP response element-binding protein) is a cellular transcription factor, which plays a role in neuronal plasticity and long-term memory formation in the brain. Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes. In this study we used ELISAs to measure CREB and Akt levels in patients with ADD and found CREB levels to be significantly higher in the ADD group and the levels in individuals correlate significantly with significantly higher AKT levels we found in the same patients in a previous study.