A prospective study to evaluate high dose daptomycin pharmacokinetics and pharmacodynamics in <i>Staphylococcus</i> spp. infective endocarditis
From a PK/PD point of view, all patients reached the value of AUC/MIC > 666, while roughly 70% of patients in group A and 90% in group B reached the target value of AUC/MIC>1061. Even if this cut-off value is arbitrary, 11-12 mg/kg daily dose could be taken into consideration in case of serious infections characterised by a high inoculum or in cases of prosthetic valve infections.
Authors
- Annalisa De Silvestri (ORCID: https://orcid.org/0000-0003-3128-8441)
- Elena Seminari (ORCID: https://orcid.org/0000-0001-5246-928X)
- Paola Giordani
- Raffaele Bruno (ORCID: https://orcid.org/0000-0002-0235-9207)
- Simona De Gregori (ORCID: https://orcid.org/0000-0002-9627-8730)
- Mara Capone (ORCID: https://orcid.org/0009-0006-9934-076X)
- Vincenzina Monzillo
Institutions
- University of Pavia (IT)
- Policlinico San Matteo Fondazione (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Therapeutic Advances in Infectious Disease
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/20499361241296232
- Citations
- 3
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- Ministero della Salute