miR-21 and cathepsin B in familial Mediterranean fever: novel findings regarding their impact on disease severity
This might be considered one of the mechanisms for subclinical inflammation in paediatric FMF patients through increased activation of cytokines via the downregulation of miR-21-5p. Our findings suggest that miR-21-5p and IL-1β play key roles in subclinical inflammation, and these molecules might be a potential therapeutic target.
Authors
- Hafize Uzun
- Ramila Hajiyeva (ORCID: https://orcid.org/0000-0002-4699-1028)
- Mehmet Yıldız (ORCID: https://orcid.org/0000-0002-7834-4909)
- Sinem Durmuş (ORCID: https://orcid.org/0000-0002-9272-9098)
- Remise Gelışgen (ORCID: https://orcid.org/0000-0003-4121-5107)
- Emrah Yücesan (ORCID: https://orcid.org/0000-0003-4512-8764)
- Özgür Kasapçopur (ORCID: https://orcid.org/0000-0002-1125-7720)
- Kenan Barut
- Amra Adroviç (ORCID: https://orcid.org/0000-0002-2400-6955)
Institutions
- Izmir Kâtip Çelebi University (TR)
- Istanbul University-Cerrahpaşa (TR)
- Institute of Neurological Sciences (IT)
- Istanbul Arel University (TR)
Publication Details
- Journal
- BMJ Paediatrics Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/bmjpo-2024-003064
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00