Interplay of NF-κB and PPAR-γ transcription factors in patients with juvenile systemic lupus erythematosus
The observed trend of elevated NF-κB levels and decreased PPAR-γ levels in our study suggests their potential as biomarkers associated with increased proinflammatory signalling in jSLE and jSSc. However, our findings must be regarded as hypothesis-generating and confirmed in larger datasets. Moreover, their roles in monitoring the course of a disease and guiding therapeutic strategies in juvenile systemic autoimmune diseases need to be clearly investigated. Further extension of these findings may lead to better management and improvement in the outcomes of such patients.
Authors
- Sinem Durmuş (ORCID: https://orcid.org/0000-0002-9272-9098)
- Kenan Barut (ORCID: https://orcid.org/0000-0001-8459-2872)
- Hafize Uzun (ORCID: https://orcid.org/0000-0002-1347-8498)
- Remise Gelışgen (ORCID: https://orcid.org/0000-0003-4121-5107)
- Özgür Kasapçopur (ORCID: https://orcid.org/0000-0002-1125-7720)
- Sezgin Şahin (ORCID: https://orcid.org/0000-0002-5365-3457)
- Amra Adroviç (ORCID: https://orcid.org/0000-0002-2400-6955)
Institutions
- Izmir Kâtip Çelebi University (TR)
- Istanbul University-Cerrahpaşa (TR)
- Istanbul Arel University (TR)
Publication Details
- Journal
- Lupus Science & Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/lupus-2024-001263
- Citations
- 7
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 11.68