Development and validation of a molecular classifier of meningiomas
Our DNA methylation-based classifier, which is publicly available for immediate clinical use, recapitulates the biology and outcomes of the original molecular groups as assessed using multiple metrics/platforms that were not used in its training.
Authors
- Jeff Liu (ORCID: https://orcid.org/0000-0002-9928-7552)
- Farshad Nassiri (ORCID: https://orcid.org/0000-0002-0797-3425)
- Aaron Cohen‐Gadol (ORCID: https://orcid.org/0000-0002-4946-1524)
- Vikas Patil
- Marcos Tatagiba
- Zeel Patel (ORCID: https://orcid.org/0000-0002-6137-0510)
- Felix Behling (ORCID: https://orcid.org/0000-0002-1083-1276)
- Chloe Gui (ORCID: https://orcid.org/0000-0002-6685-1970)
- Silky Chotai (ORCID: https://orcid.org/0000-0001-5981-3231)
- Alexander D. Rebchuk (ORCID: https://orcid.org/0000-0001-5553-346X)
- Olivia Singh (ORCID: https://orcid.org/0000-0001-7321-6775)
- Stephen Yip (ORCID: https://orcid.org/0000-0002-8514-9861)
- Mohamed A. Zaazoue (ORCID: https://orcid.org/0000-0002-6755-6308)
- Derek S. Tsang (ORCID: https://orcid.org/0000-0002-9762-6901)
- Jill S. Barnholtz‐Sloan (ORCID: https://orcid.org/0000-0001-6190-9304)
- Alireza Mansouri (ORCID: https://orcid.org/0000-0002-7442-7539)
- Serge Makarenko (ORCID: https://orcid.org/0000-0002-6283-249X)
- Andrew Ajisebutu
- Justin Z. Wang (ORCID: https://orcid.org/0000-0001-8998-7443)
- Kenneth Aldape (ORCID: https://orcid.org/0000-0001-5119-7550)
- Yosef Ellenbogen (ORCID: https://orcid.org/0000-0003-1390-1361)
- Gelareh Mohammed Zadeh (ORCID: https://orcid.org/0000-0002-6637-4502)
- Qingxia Wei (ORCID: https://orcid.org/0000-0002-7723-6180)
- Julio Sosa (ORCID: https://orcid.org/0000-0001-5516-5724)
- Lola B. Chambless (ORCID: https://orcid.org/0000-0001-5864-5387)
- C. W. Wilson (ORCID: https://orcid.org/0009-0009-1016-4432)
- Andrew Edward Sloan (ORCID: https://orcid.org/0000-0001-9607-5063)
- Sheila Mansouri (ORCID: https://orcid.org/0000-0002-7255-207X)
- Ghazaleh Tabatabai (ORCID: https://orcid.org/0000-0002-3542-8782)
- Andrew Gao (ORCID: https://orcid.org/0000-0002-2204-3277)
- Alexander Landry (ORCID: https://orcid.org/0000-0002-7250-8466)
Institutions
- University Health Network (CA)
- University of British Columbia (CA)
- German Cancer Research Center (DE)
- University of Toronto (CA)
- Washington University in St. Louis (US)
- Keck Hospital of USC (US)
- Princess Margaret Cancer Centre (CA)
- Piedmont Cancer Institute (US)
- Center for Neuro-Oncology (US)
- Central Brain Tumor Registry of the United States (US)
- National Cancer Institute (US)
- Hertie Institute for Clinical Brain Research (DE)
- Center for Cancer Research (US)
- Neurological Surgery (US)
- Division of Cancer Epidemiology and Genetics
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- University of Oklahoma Health Sciences Center (US)
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- University of Tübingen (DE)
- Penn State Milton S. Hershey Medical Center (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1093/neuonc/noae242
- Citations
- 14
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 5.41
Funders
- U.S. Department of Health and Human Services
- Congress of Neurological Surgeons
- Vanderbilt University
- University of Pennsylvania
- University of Oklahoma
- Case Western Reserve University
- Pennsylvania State University
- Case Comprehensive Cancer Center, Case Western Reserve University
- School of Medicine, Case Western Reserve University
- Deutsches Krebsforschungszentrum
- Princess Margaret Hospital Foundation
- Faculty of Medicine, University of British Columbia
- Vanderbilt University Medical Center
- Broad Institute
- Leidos
- NRG Oncology
- University of Toronto
- Deutschen Konsortium für Translationale Krebsforschung
- National Institutes of Health
- University of Oklahoma Health Sciences Center
- University Health Network Foundation
- Canadian Institutes of Health Research
- National Cancer Institute
- School of Medicine, University of North Carolina at Chapel Hill
- Moonshot Research and Development Program
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Cancer Moonshot
- Center for Biomedical Informatics and Information Technology, National Cancer Institute