Immunoregulatory programs in anti‐<i>N</i>‐methyl‐D‐aspartate receptor encephalitis identified by single‐cell multi‐omics analysis
Significant B cell clonal expansion, particularly in plasma cells, driven by antigen recognition. IFN-I pathway activation in plasma cells boosts their antibody production and potentially exacerbates immune dysregulation. TLR2 pathway activation in myeloid cells contributes to TNF-α secretion and could influence adaptive immune responses.
Authors
- Yaqing Shu (ORCID: https://orcid.org/0000-0003-2768-1654)
- Huilu Li
- Wenxu Ren
- Xinhui Li (ORCID: https://orcid.org/0000-0003-1837-4249)
- Jin Xu (ORCID: https://orcid.org/0000-0003-0944-9835)
- Zihao Chen (ORCID: https://orcid.org/0000-0002-7275-7593)
- Zhongjie Tang (ORCID: https://orcid.org/0009-0003-0534-5411)
- Dongjie Peng
- Yicong Xu
- Weixing Zhang
Institutions
- Sun Yat-sen University (CN)
- Heidelberg University (DE)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/ctm2.70173
- Citations
- 4
- Primary Topic
- Autoimmune Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.56
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Natural Science Foundation of Guangdong Province
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Basic and Applied Basic Research Foundation of Guangdong Province