Therapeutic Potential of Agmatine in Essential Tremor Through Regulation of Lingo‐1 and Inflammatory Pathways
Collectively, this study provides the first evidence that agmatine dampens tremor severity, improves behavioral outcomes, and modulates key pathways implicated in ET pathogenesis in a rodent model. The ability of agmatine to normalize Lingo-1 and IL-6 expression suggests regulation of these pathways could underlie its neuroprotective action. These results suggest promise for agmatine as a prospective therapeutic agent in ET.
Authors
- Kristi A. Kohlmeier (ORCID: https://orcid.org/0000-0003-0183-3816)
- Mohammad Shabani (ORCID: https://orcid.org/0000-0002-2082-5849)
- Moazamehosadat Razavinasab (ORCID: https://orcid.org/0000-0003-2007-3584)
- Mohsen Nakhaie (ORCID: https://orcid.org/0000-0001-7605-2593)
- Zahra Esmaili (ORCID: https://orcid.org/0000-0003-3776-236X)
- Mehran Ilaghi (ORCID: https://orcid.org/0000-0002-6674-5406)
- Zeynab Pirmoradi
Institutions
- University of Copenhagen (DK)
- Kerman University of Medical Sciences (IR)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/brb3.70241
- Citations
- 2
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.24
Funders
- Kerman University of Medical Sciences
- Kerman Neuroscience Research Center, Kerman University of Medical Sciences