The prognostic role of cardiac and inflammatory biomarkers in extubation failure in patients with COVID-19 acute respiratory distress syndrome
Hs-TnT, NT-proBNP and PCT measured on the day of extubation are associated with extubation failure in mechanically ventilated patients with C-ARDS. Since Hs-TnT is the only biomarker that is independently associated with extubation failure, Hs-TnT could offer additional objective measures for assessing readiness for extubation. Future studies should focus on an integrative approach of biomarkers combined with relevant clinical factors to predict extubation failure.
Authors
- Vivan J.M. Baggen (ORCID: https://orcid.org/0000-0003-0692-9147)
- Leo Heunks (ORCID: https://orcid.org/0000-0003-3196-4665)
- Eric A. Dubois (ORCID: https://orcid.org/0000-0002-6727-8635)
- Carline N. L. Groenland (ORCID: https://orcid.org/0000-0002-5759-2217)
- Evert‐Jan Wils (ORCID: https://orcid.org/0000-0002-2868-0920)
- Diederik A M P J Gommers (ORCID: https://orcid.org/0000-0001-6808-7702)
- Henrik Endeman
- Adinde H. Siemers
Institutions
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Sint Franciscus Gasthuis (NL)
- OLVG (NL)
- Erasmus MC Cancer Institute (NL)
- Franciscus Vlietland (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Annals of Intensive Care
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1186/s13613-025-01425-3
- Citations
- 1
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Roche Nederland