Exploring the Relationship Between Sleep Apnea, Myocardial Infarct Size, and Coronary Collaterals in Acute Myocardial Infarction: A Multidisciplinary Study
Our study did not find statistically significant differences in cardiac infarct size and the presence of coronary collaterals by sleep apnea severity among patients with AMI. However, our results are hypothesis-generating, and suggest that moderate SA may potentially offer cardioprotective benefits through enhanced coronary collaterals. These insights call for future research to explore the heterogeneity in ischemic preconditioning by SA severity and hypoxic burden to guide tailored clinical strategies for SA management in patients with AMI.
Authors
- Carlos G. Santos‐Gallego (ORCID: https://orcid.org/0000-0003-1408-8958)
- Hiroshi Ueda (ORCID: https://orcid.org/0000-0001-8849-4217)
- Annapoorna Kini (ORCID: https://orcid.org/0000-0002-7189-3307)
- Yuliya Vengrenyuk
- Naotaka Okamoto (ORCID: https://orcid.org/0000-0002-0228-679X)
- Kavya Devarakonda (ORCID: https://orcid.org/0000-0002-4374-4670)
- Mark Menegus
- Jorge R. Kizer (ORCID: https://orcid.org/0000-0001-9936-7803)
- Susan Redline (ORCID: https://orcid.org/0000-0002-6585-1610)
- Neomi Shah (ORCID: https://orcid.org/0009-0003-5804-0507)
- Vaishnavi Kundel (ORCID: https://orcid.org/0000-0002-2923-9539)
- Mayte Suárez‐Fariñas (ORCID: https://orcid.org/0000-0001-8712-3553)
- Oren Cohen
- Robert C. Kaplan (ORCID: https://orcid.org/0000-0003-1571-4615)
- Umesh Gidwani
- Samira Khan (ORCID: https://orcid.org/0000-0003-4480-9162)
Institutions
- Brigham and Women's Hospital (US)
- Albert Einstein College of Medicine (US)
- Harvard University (US)
- University of California, San Francisco (US)
- Fred Hutch Cancer Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Nature and Science of Sleep
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/nss.s489788
- Citations
- 3
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- American Thoracic Society
- American Academy of Sleep Medicine
- National Institutes of Health
- National Heart, Lung, and Blood Institute