Molecular docking, ADMET, synthesis and anti-proliferative of novel derivatives of benzothiazine against lung cancer cell line

One of the most intriguing epigenetic targets for medication therapy is epidermal growth factor receptor tyrosine kinase (EGFR-TK). Overexpression of EGFR-TK is seen in many illnesses, including cancers. In the cnew EGFR-TK inhibitors were designed with the same consisting of erlotinib (approved anticancer drug) with longer linker and substituted hydrophobic moiety using Ligand Designer from Glide (Schrodinger LLC). By experimenting with different amide and Schiff base residues, the linker was o