Lifetime Treatment Trajectories of Mantle Cell Lymphoma: Simulation Based Analysis of 20 Years of Real‐World Data
Mantle cell lymphoma is a rare type of B-cell lymphoma, which is considered incurable yet treatable. In recent years, the treatment options of mantle cell lymphoma have multiplied, and the focus of treatment is expected to shift from traditional chemoimmunotherapy toward precision medicine. However, this development is hindered by the high costs of targeted therapies. To provide a baseline for future assessment of costs and benefits of new and emerging MCL treatments, we established a predictive simulated model of lifetime treatment trajectories based on a retrospective cohort of chemoimmunotherapy era patients diagnosed and treated between the year 2000 and 2020.
Authors
- Marc Sorigué (ORCID: https://orcid.org/0000-0002-0587-591X)
- Aino Rajamäki (ORCID: https://orcid.org/0000-0003-1105-3549)
- Outi Kuittinen (ORCID: https://orcid.org/0000-0001-9969-0053)
- Arja Jukkola‐Vuorinen (ORCID: https://orcid.org/0000-0002-6107-1764)
- Aino Rönkä (ORCID: https://orcid.org/0000-0001-6007-3648)
- Kaisa Sunela (ORCID: https://orcid.org/0000-0002-2639-5448)
- Roosa Prusila (ORCID: https://orcid.org/0000-0002-8908-1542)
- Tuula Klaavuniemi
- Reijo Sund (ORCID: https://orcid.org/0000-0002-6268-8117)
- Erika Alanne (ORCID: https://orcid.org/0000-0003-1925-0192)
- Mika Hujo
- Hanne Kuitunen (ORCID: https://orcid.org/0000-0001-7328-2043)
- Juan‐Manuel Sancho (ORCID: https://orcid.org/0000-0001-7168-6538)
- Esa Kari (ORCID: https://orcid.org/0000-0002-7165-8120)
- Minna Harmanen (ORCID: https://orcid.org/0000-0001-8799-9985)
- Esa Jantunen
- Madiha Khan (ORCID: https://orcid.org/0000-0001-9461-4369)
Institutions
- University of Eastern Finland (FI)
- Oulu University Hospital (FI)
- Turku University Hospital (FI)
- Kuopio University Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Hospital Universitari Germans Trias i Pujol (ES)
- University of Oulu (FI)
Publication Details
- Journal
- Hematological Oncology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/hon.70024
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00