Frequency of Hyperprolactinemia in Patients with Overt and Subclinincal Hypothyroidism.

Objective: To see the frequency of hyperprolactinemia in patients with subclinical and overt hypothyroidism. Methodology: This is a descriptive cross-sectional, was performed at the Department of Endocrinology, MTI Lady Reading Hospital, Peshawar, Pakistan. Patients with overt and subclinical hypothyroidism were included in this study. Pregnant or lactating women, patients with a history of renal or hepatic impairment, and patients taking medications that could cause hyperprolactinemia, such as antidepressants, antipsychotics, metoclopramide, and estrogen-containing oral contraceptive pills, were excluded from the study. The frequency of hyperprolactinemia was recorded in these patients. Results: Among 377 patients who had subclinical or overt hypothyroidism, 140 (37.1%) patients were males, while 237 (62.9%) were females. Two hundred and ninety-five (78.2%) patients had subclinical hypothyroidism, while 82 (21.8%) patients were overtly hypothyroid. Among patients with hyperprolactinemia and subclinical or overt hypothyroidism, 25 (27.2 %) were males and 67 (62.8%) were females (p=0.02). Among patients with hyperprolactinemia, 25 (30.4%) were having hypothyroidism while 67 (22.7%) patients were having subclinical hypothyroidism (p=0.14). Conclusion: Both subclinical and overt hypothyroidism is pretty prevalent in patients with high prolactin levels, especially in females.