Clinicopathological features and cyclooxygenase-2 expression in cervical cancer patients

BACKGROUND: Cervical cancer is a global burden that continues to increase throughout the world. Cyclooxygenase-2 (COX-2) expression is increased in preinvasive lesions, early to advanced stages of cervical cancer, and its upregulation mainly occurs in patients with differentiation, metastasis, and poor prognosis. The aim of this study was to analyze the comparison of clinical and pathological features as well as COX-2 expression on the risk of mortality in patients with cervical cancer.METHODS: A cohort retrospective study was taken on cervical cancer patients in Dr. Wahidin Sudirohusodo Hospital, Makassar, South Sulawesi, Indonesia. Demographic, clinical features and laboratory data were collected by collecting medical record data from patients who were examined in Clinical Laboratory and Pathology Laboratory of Dr. Wahidin Sudirohusodo Hospital. Baseline data were descriptively summarized. Each of clinicopathological features and COX-2 expression are analyzed with mortality risk by χ2 test or Fischer’s Exact Test.RESULTS: Factors significantly correlated with mortality among cervical cancer is parity 1.22 (0.92-1.61) with P=0.041 and younger age (P=0.038). There are no factors correlated with COX-2 expression.CONCLUSIONS: Multiparity is the only factor that induces mortality risk among cervical cancer patients. Any variable does not influence COX-2 expression in this study.