Design of CMOS chip for retinal prosthesis with power supply voltage monitoring circuit for stabilizing constant-current stimulation
Abstract To advance the practical application of retinal prostheses with high spatial resolution through parallel stimulation, we developed a dynamic power supply voltage control system designed to enable stable constant-current stimulation in vivo, regardless of the number of active stimulation points. The proposed retinal prosthesis integrates a CMOS chip, containing current sources and electrode selection circuits, into a stimulation electrode array implanted in the eye. This configuration facilitates individual control of over 1000 electrodes with minimal wiring. In this study, we designed and integrated a power supply voltage monitoring circuit into the chip, allowing for real-time control of an external power generation circuit through feedback from the intraocular monitoring circuit. We demonstrated that the proposed system rapidly restored the power supply voltage when a voltage drop of 1 V occurred in the Pt wiring between the power supply unit and the chip, even while delivering a stimulation current of 1.5 mA in parallel across more than 100 electrodes.
Authors
- Kenzo Shodo (ORCID: https://orcid.org/0009-0009-9317-0925)
- Yuki Nakanishi (ORCID: https://orcid.org/0000-0003-3034-4077)
- Jun Ohta (ORCID: https://orcid.org/0000-0001-8194-9020)
- Kiyotaka Sasagawa (ORCID: https://orcid.org/0000-0002-5718-3958)
- Makito Haruta (ORCID: https://orcid.org/0000-0002-7155-9018)
- Kuang-Chih Tso (ORCID: https://orcid.org/0000-0002-1939-6127)
- Takaya Hattori (ORCID: https://orcid.org/0009-0005-5721-336X)
- Hiroyuki Tashiro (ORCID: https://orcid.org/0000-0001-5669-154X)
- Hironari Takehara (ORCID: https://orcid.org/0000-0001-7689-1186)
- Yasuo Terasawa (ORCID: https://orcid.org/0000-0002-4535-8589)
- Yoshinori Sunaga (ORCID: https://orcid.org/0000-0002-8334-9667)
- Wisaroot Sriitsaranusorn (ORCID: https://orcid.org/0009-0009-9323-8205)
Institutions
- Chitose Institute of Science and Technology (JP)
- Kyushu University (JP)
- Nidek (Japan) (JP)
- Nara Institute of Science and Technology (JP)
Publication Details
- Journal
- Japanese Journal of Applied Physics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.35848/1347-4065/ad99e0
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- University of Tokyo
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology