Prognostic significance of MRD and its correlation with arsenic concentration in pediatric acute promyelocytic leukemia: a retrospective study by SCCLG-APL group
Our study highlights the prognostic significance of post-induction MRD assessment in pediatric APL. We also demonstrate a negative correlation between blood arsenic concentration levels and MRD, suggesting that lower arsenic concentrations during induction therapy may contribute to a higher MRD burden. These findings may inform strategies to optimize treatment and improve outcomes in pediatric APL.<b>Trial registration:</b> www.clinicaltrials.gov (NCT02200978).
Authors
- Cong Liang (ORCID: https://orcid.org/0000-0002-6796-8417)
- Yan‐Lai Tang (ORCID: https://orcid.org/0000-0002-2649-5270)
- Wuqing Wan
- X. Zhang (ORCID: https://orcid.org/0009-0001-6819-023X)
- Danping Huang (ORCID: https://orcid.org/0000-0003-4252-3611)
- Lihua Yang (ORCID: https://orcid.org/0000-0003-2570-076X)
- Zijun Zhen (ORCID: https://orcid.org/0000-0002-4442-0897)
- Riyang Liu (ORCID: https://orcid.org/0000-0001-6520-3931)
- Yu-Li
- Yi-Qiao Chen
- Huirong Mai (ORCID: https://orcid.org/0000-0002-8970-9221)
- Bin Li (ORCID: https://orcid.org/0000-0002-5717-1551)
- Lina Wang (ORCID: https://orcid.org/0000-0002-9194-3527)
- Xue-Qun Luo
- Guohua Chen (ORCID: https://orcid.org/0000-0001-8912-543X)
- Wanli Li (ORCID: https://orcid.org/0000-0002-7070-2783)
- Li-Bin Huang
- Jie‐Si Luo
- Xiaoqin Feng (ORCID: https://orcid.org/0000-0003-1166-0138)
- Huiqin Chen (ORCID: https://orcid.org/0000-0003-2477-5436)
- Zhong Fan (ORCID: https://orcid.org/0000-0003-2632-011X)
- Dun‐hua Zhou (ORCID: https://orcid.org/0000-0002-8173-4924)
- Bi‐Yun Guo
- Hekui Lan
- Liangchun Yang
Institutions
- Fujian Medical University (CN)
- Central South University (CN)
- Sun Yat-sen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Hunan Children's Hospital (CN)
- Huizhou Central People's Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Shenzhen Children's Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
- Union Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Therapeutic Advances in Hematology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/20406207241311774
- Citations
- 3
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province