Integrating multi‐omics features enables non‐invasive early diagnosis and treatment response prediction of diffuse large B‐cell lymphoma
A comprehensive multi-omics solution to specifically obtain an extensive fragmentomics landscape, presented by breakpoint characteristics of nucleosomes, CpG islands, DNase clusters and enhancers, besides typical methylation, copy number alteration of cfDNA. Integrated model of cfDNA multi-omics could be used for non-invasive early diagnosis of DLBCL. Integrated model of cfDNA multi-omics could effectively evaluate the efficacy of R-CHOP before DLBCL treatment.
Authors
- Jiahao Lyu (ORCID: https://orcid.org/0000-0001-6788-3942)
- Wenxin Qi (ORCID: https://orcid.org/0009-0004-1642-7188)
- Dan Yuan (ORCID: https://orcid.org/0000-0002-9074-8770)
- Yanzhao Li (ORCID: https://orcid.org/0000-0002-3170-0291)
- Xiaoyu Hao (ORCID: https://orcid.org/0000-0003-4115-9475)
- Wenzhe Si (ORCID: https://orcid.org/0000-0003-1573-9337)
- Yang Song (ORCID: https://orcid.org/0000-0002-2454-8498)
- Hairong Jing
- Ping Yang (ORCID: https://orcid.org/0000-0001-5466-8426)
- Hongmei Jing (ORCID: https://orcid.org/0000-0003-4958-2489)
- Yuqi Zhang (ORCID: https://orcid.org/0000-0001-6629-4564)
- Yan Liu (ORCID: https://orcid.org/0000-0002-3961-9172)
- Jing Wang (ORCID: https://orcid.org/0000-0002-5398-0802)
- Yan Li (ORCID: https://orcid.org/0000-0002-1612-5719)
- Xu Zhang (ORCID: https://orcid.org/0000-0002-4356-0281)
- Fan Yang (ORCID: https://orcid.org/0000-0003-0717-5420)
- Zijian Zhao (ORCID: https://orcid.org/0000-0002-6140-3423)
- Lingli Wang (ORCID: https://orcid.org/0000-0003-2756-5346)
- Zhihong Wu (ORCID: https://orcid.org/0000-0003-3691-2389)
- Weilong Zhang (ORCID: https://orcid.org/0009-0009-4052-200X)
- Chaoling Wu (ORCID: https://orcid.org/0000-0002-4517-0818)
- Fei Dong (ORCID: https://orcid.org/0000-0002-7969-293X)
- Kang Peng
- Baoying Ye
Institutions
- Peking University (CN)
- BOE Technology Group (China) (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/ctm2.70174
- Citations
- 6
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 5.62