Vaginal Transcriptional Signatures of the Neutrophil‐Driven Immune Response Correlate With Clinical Severity During Recurrent Vulvovaginal Candidiasis
The clinical severity of RVVC during active infection correlates with increased expression of genes involved in molecular inflammation and neutrophil activation in the vaginal mucosa. The lack of differences between healthy controls and women with RVVC who were between acute infections indicates that the molecular effects observed in the RVVC group are only present during active infection.
Authors
- Nina Bohm‐Starke (ORCID: https://orcid.org/0000-0001-7227-9520)
- Kristina Broliden (ORCID: https://orcid.org/0000-0003-2224-7664)
- Sara Hunt
- Anastasios Damdimopoulos (ORCID: https://orcid.org/0000-0003-4425-1189)
- Mathias Franzén Boger (ORCID: https://orcid.org/0009-0009-0219-3655)
- Gabriella Edfeldt (ORCID: https://orcid.org/0000-0003-0366-5588)
- Ina Schuppe‐Koistinen (ORCID: https://orcid.org/0000-0002-1423-3089)
- Vilde Kaldhusdal (ORCID: https://orcid.org/0000-0002-2485-5156)
- Cathrin Alvendal (ORCID: https://orcid.org/0000-0003-4329-9965)
- Tyra Hasselrot (ORCID: https://orcid.org/0009-0002-5951-5618)
Institutions
- Karolinska University Hospital (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/aji.70040
- Citations
- 4
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 4.73
Funders
- Karolinska Institutet
- Vetenskapsrådet