Causal Relationship Between Antibody‐Mediated Immune Responses of <i>Chlamydia trachomatis</i> Infection and Reproductive Tract Complications: A Bidirectional Mendelian Randomization Study
This study demonstrates the protective effects of C. trachomatis antibodies, particularly MOMP A and MOMP D, against TFI and EP, respectively. It also emphasizes the potential role of cervical inflammation in shaping immune responses to C. trachomatis. These insights provide a foundation for future research to develop immune-targeted therapies and integrated approaches for preventing and managing C. trachomatis-related reproductive tract complications.
Authors
- Yi Wang (ORCID: https://orcid.org/0000-0002-8391-1453)
- Yanggang Hong (ORCID: https://orcid.org/0009-0004-4507-0093)
Institutions
- Wenzhou Medical University (CN)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/aji.70036
- Citations
- 6
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 7.10