SARS‐CoV‐2 Activated Peripheral Blood Mononuclear Cells (PBMCs) Do Not Provoke Adverse Effects in Trophoblast Spheroids
Together, the findings of our in vitro coculture model, although not fully representative of in vivo conditions, strongly support the claim that the interaction of SARS-CoV-2-activated peripheral blood immune cells with trophoblast cells at the fetal-maternal interface does not negatively affect trophoblast functionality. This goes in hand with the recommendation of vaccinating pregnant women in their first trimester.
Authors
- Susanne M. Arnold (ORCID: https://orcid.org/0000-0001-6542-9551)
- Mario Bauer (ORCID: https://orcid.org/0000-0001-5752-038X)
- Ana Claudia Zenclussen (ORCID: https://orcid.org/0000-0003-3544-4552)
- Arkadiusz Pierzchalski
- Violeta Stojanovska (ORCID: https://orcid.org/0000-0002-5772-2843)
- Humblenoble Stembridge Ayuk (ORCID: https://orcid.org/0000-0001-9245-6811)
Institutions
- Helmholtz Centre for Environmental Research (DE)
- Saxon Academy of Sciences and Humanities in Leipzig (DE)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/aji.70039
- Primary Topic
- COVID-19 Impact on Reproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Helmholtz-Gemeinschaft