High Content Image Analysis of Cellular Responses of the Murine J774A.1 Cell Line and Primary Human Cells Alveolar Macrophages to an Extended Panel of Pharmaceutical Agents
Valuable information for selecting a suitable cell type for HCIA screening of macrophage responses to drug compounds is provided. All cell types were suitable for screening drug-induced phospholipidosis. Still, human primary alveolar macrophages responded differently to drug treatment compared to macrophage cell lines and may be required to evaluate broader response-patterns and mechanisms of toxicity.
Authors
- Stephan Eisenmann (ORCID: https://orcid.org/0000-0002-0387-0760)
- Julia Kollan
- Laura Urbano (ORCID: https://orcid.org/0000-0001-8524-3359)
- Gabriela Hädrich (ORCID: https://orcid.org/0000-0002-2360-8882)
- Lea Ann Dailey (ORCID: https://orcid.org/0000-0002-4908-7122)
- Lysann Tietze (ORCID: https://orcid.org/0000-0003-2934-1880)
- Ben Forbes (ORCID: https://orcid.org/0000-0001-8193-6107)
- Jacqueline Schwarzinger
Institutions
- University of Vienna (AT)
- University of Hertfordshire (GB)
- King's College London (GB)
- University Hospital Leipzig (DE)
- University Hospital in Halle (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Pharmaceutical Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1007/s11095-024-03806-y
- Citations
- 2
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 3.01
Funders
- Bundesministerium für Bildung und Forschung
- Universität Wien
- Stiftung zur Förderung der Erforschung von Ersatz- und Ergänzungsmethoden zur Einschränkung von Tierversuchen