Developing an adaptive paediatric intensive care unit platform trial with key stakeholders: a qualitative study
Young people, parents/carers and PICU staff viewed the proposed PICU platform trial to be acceptable. These key stakeholders supported us with the design of an adaptive platform trial for PICU that has a rigorous methodology, yet can be operationalised in a family-centred way, to provide high-quality evidence that can support clinical decision-making and guide the treatment of critically ill children. Our findings have informed the PICU platform trial protocol.
Authors
- Padmanabhan Ramnarayan (ORCID: https://orcid.org/0000-0003-0784-8154)
- Elizabeth Deja (ORCID: https://orcid.org/0000-0002-3626-4927)
- Doug William Gould (ORCID: https://orcid.org/0000-0003-4148-3312)
- Jennifer Preston (ORCID: https://orcid.org/0000-0003-4800-234X)
- Carly Tibbins
- Julie Menzies (ORCID: https://orcid.org/0000-0003-2080-3364)
- James Ainsworth (ORCID: https://orcid.org/0000-0001-5571-1983)
- Mark Peters (ORCID: https://orcid.org/0000-0003-3653-4808)
- Shelley Marsh
- Paul R. Mouncey (ORCID: https://orcid.org/0000-0002-8510-8517)
- Kerry Woolfall (ORCID: https://orcid.org/0000-0002-5726-5304)
- Tracy Karen Mitchell (ORCID: https://orcid.org/0000-0003-0014-8016)
- Hannah Sedgwick
Institutions
- University of Liverpool (GB)
- Great Ormond Street Hospital (GB)
- Bristol Royal Hospital for Children (GB)
- Alder Hey Children's Hospital (GB)
- NIHR Research Delivery Network (GB)
- Intensive Care National Audit & Research Centre (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- BMJ Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/bmjopen-2024-085142
- Citations
- 3
- Primary Topic
- Childhood Cancer Survivors' Quality of Life
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Institute for Health and Care Research
- Health Technology Assessment Programme