Disruption of tumor-intrinsic PGAM5 increases anti-PD-1 efficacy through the CCL2 signaling pathway
Our results shed light on the effect of tumor mitochondria dynamics on TAMs in tumor microenvironment. Tumor-intrinsic PGAM5 can be a therapeutic target to improve immunotherapy efficacy in patients with HCC.
Authors
- Ting Mei (ORCID: https://orcid.org/0000-0001-7756-040X)
- Anlin Wang (ORCID: https://orcid.org/0009-0003-7561-3856)
- Xiaoying Wei (ORCID: https://orcid.org/0000-0001-5665-209X)
- Yuan He (ORCID: https://orcid.org/0000-0001-7692-5577)
- Peijie Zhou (ORCID: https://orcid.org/0000-0002-4585-2923)
- Huiquan Liu (ORCID: https://orcid.org/0000-0002-4723-845X)
- Jianguo Wang (ORCID: https://orcid.org/0000-0003-2988-7867)
- Jingjing Cheng (ORCID: https://orcid.org/0000-0001-8366-4117)
- Yan Li (ORCID: https://orcid.org/0000-0003-1424-7322)
- Yixuan Li (ORCID: https://orcid.org/0000-0001-9568-3809)
- Dong Han (ORCID: https://orcid.org/0000-0002-9074-6708)
- Xiaoyang Li (ORCID: https://orcid.org/0000-0003-3684-2106)
- Dong Qian (ORCID: https://orcid.org/0000-0002-3232-5104)
- Yuwen Wang (ORCID: https://orcid.org/0000-0002-7612-7935)
- Hong Wang (ORCID: https://orcid.org/0000-0003-2724-8156)
- Ziye Li (ORCID: https://orcid.org/0009-0006-7816-5341)
- Zilong Xu (ORCID: https://orcid.org/0000-0001-5212-1910)
- J. H. Ning
Institutions
- University of Science and Technology of China (CN)
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Yuhuangding Hospital (CN)
- Anhui Provincial Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/jitc-2024-009993
- Citations
- 14
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 14.64
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Anhui Province