Divergent response to radio-immunotherapy is defined by intrinsic features of the tumor microenvironment
This work highlights the complexity of combining immunotherapies within the tumor microenvironment (TME) and further defines the immune and non-immune components of the TME as an intrinsic feature of immune suppression.
Authors
- Khalid N.M. Abdelazeem (ORCID: https://orcid.org/0000-0002-0672-7900)
- Michael W. Knitz (ORCID: https://orcid.org/0000-0002-5786-9837)
- Alexander Nguyen (ORCID: https://orcid.org/0009-0004-1108-2176)
- Laurel B. Darragh (ORCID: https://orcid.org/0000-0002-6445-7988)
- Sana D. Karam (ORCID: https://orcid.org/0000-0003-1676-5967)
- Brooke Neupert
- Miles Piper (ORCID: https://orcid.org/0000-0002-8458-2524)
- Laurene Pousse
- Nicholas A. Olimpo (ORCID: https://orcid.org/0000-0001-6556-2168)
- Maria Amann (ORCID: https://orcid.org/0009-0006-0104-0057)
- Diemmy Nguyen (ORCID: https://orcid.org/0000-0002-2035-643X)
- Jessica I. Beynor (ORCID: https://orcid.org/0000-0001-9430-0271)
- Jacob Gadwa (ORCID: https://orcid.org/0000-0003-0560-2337)
- Christian Klein (ORCID: https://orcid.org/0000-0001-7594-7280)
- Mudita Pincha
- Anthony J. Saviola (ORCID: https://orcid.org/0000-0001-6890-512X)
- Ali Bransi
- Sophia Corbo (ORCID: https://orcid.org/0000-0002-1179-6425)
- Justin Yu (ORCID: https://orcid.org/0000-0003-2778-3175)
- Chloe Hodgson
Institutions
- Roche (Switzerland) (CH)
- Washington University in St. Louis (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/jitc-2024-010405
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Hope Foundation
- National Cancer Institute
- National Institute of Dental and Craniofacial Research