Differential impact of TIM-3 ligands on NK cell function
Our findings underscore the complex functional impact of TIM-3 ligand signaling, which is consistent with recent clinical trials suggesting that targeting TIM-3 alone is suboptimal as an immunotherapeutic approach for treating malignancies.
Authors
- Jennifer L. Anderson (ORCID: https://orcid.org/0000-0002-1471-5803)
- Lazar Vujanović (ORCID: https://orcid.org/0000-0003-1729-8619)
- Riyue Bao (ORCID: https://orcid.org/0000-0002-6105-1704)
- Housaiyin Li
- Tullia C. Bruno (ORCID: https://orcid.org/0000-0002-6433-0207)
- Larry Kane (ORCID: https://orcid.org/0000-0001-5198-516X)
- Pawan Upadhyay (ORCID: https://orcid.org/0000-0003-4945-5375)
- Hridesh Banerjee (ORCID: https://orcid.org/0000-0002-4536-4102)
- Aditi Kulkarni (ORCID: https://orcid.org/0000-0002-4886-6095)
- Lídia Maria Rebolho Batista Arantes (ORCID: https://orcid.org/0000-0001-8230-1218)
- Robert L. Ferris (ORCID: https://orcid.org/0000-0001-6605-2071)
- Xin Zhang (ORCID: https://orcid.org/0000-0001-9392-5456)
- Onyedikachi Victor Onyekachi
- Juncheng Wang (ORCID: https://orcid.org/0000-0001-9909-274X)
Institutions
- University of North Carolina Health Care (US)
- Central South University (CN)
- University of Pittsburgh (US)
- Hospital de Câncer de Barretos (BR)
- UPMC Hillman Cancer Center (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/jitc-2024-010618
- Citations
- 13
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 10.37
Funders
- University of Pittsburgh
- National Institutes of Health
- Novartis Institutes for BioMedical Research
- Center for Research Computing, University of Pittsburgh