Chemotherapy-induced cellular senescence promotes stemness of aggressive B-cell non-Hodgkin’s lymphoma via CCR7/ARHGAP18/IKBα signaling activation
Together, TIS promotes the stemness of B-NHL cells via CCR7/ARHGAP18/IKBα signaling activation and targeting CCR7/ARHGAP18 might overcome the chemoresistance of senescent B-NHL cells by inhibiting stemness acquisition and maintenance.
Authors
- Liuying Yi
- Linhui Hu (ORCID: https://orcid.org/0000-0002-1990-4523)
- Chaohong Liu (ORCID: https://orcid.org/0000-0001-7028-4625)
- Jiyu Wang (ORCID: https://orcid.org/0000-0003-1350-8770)
- Yanjie Ruan (ORCID: https://orcid.org/0000-0003-1836-2838)
- Huiping Wang
- Anwen Ren
- Zhixiang Wanyan
- Yangyang Wang (ORCID: https://orcid.org/0000-0001-5810-8928)
- Fan Wu (ORCID: https://orcid.org/0000-0003-1039-3752)
- Zhimin Zhai (ORCID: https://orcid.org/0000-0003-4060-7600)
- Wan Yang
- Keke Huang
- Qianshan Tao (ORCID: https://orcid.org/0000-0003-1269-5850)
- J. Li (ORCID: https://orcid.org/0000-0003-4819-4978)
Institutions
- Nanchang University (CN)
- Anhui Medical University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
- Huazhong University of Science and Technology (CN)
- Zhejiang University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/jitc-2024-009356
- Citations
- 3
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Anhui Province