CD63-high macrophage-derived exosomal miR-6876-5p promotes hepatocellular carcinoma stemness via PTEN/Akt-mediated EMT pathway
CD63-high macrophage-derived exosomes, particularly those enriched with miR-6876-5p, play a pivotal role in HCC progression by enhancing stemness and promoting epithelial-mesenchymal transition through the PTEN/Akt pathway. Targeting these exosomes and their microRNAs offers a promising therapeutic strategy forHCC.
Authors
- Xiuli Jin
- Dong Hang (ORCID: https://orcid.org/0000-0001-6944-0459)
- Shuairan Zhang (ORCID: https://orcid.org/0009-0009-0498-3079)
- Jing Sun (ORCID: https://orcid.org/0000-0003-0046-6663)
- Shiqi Liu (ORCID: https://orcid.org/0000-0001-9070-6493)
- Ji Sun (ORCID: https://orcid.org/0000-0001-9260-2292)
- Yiling Li (ORCID: https://orcid.org/0000-0002-6407-1778)
- Gang Wu (ORCID: https://orcid.org/0000-0001-6305-1639)
Institutions
- Dana (United States) (US)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1097/hc9.0000000000000616
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22