Safety and efficacy of the therapeutic DNA-based vaccine VB10.16 in combination with atezolizumab in persistent, recurrent or metastatic HPV16-positive cervical cancer: a multicenter, single-arm phase 2a study
The therapeutic DNA-based vaccine VB10.16 combined with atezolizumab was safe and well tolerated showing a promising clinically meaningful efficacy with durable responses in patients with persistent, r/m HPV16-positive cervical cancer, especially if PD-L1-positive.
Authors
- Peter Hillemanns (ORCID: https://orcid.org/0000-0001-9829-3531)
- Hannelore Denys (ORCID: https://orcid.org/0000-0002-8897-9430)
- Theresa Link (ORCID: https://orcid.org/0000-0002-2229-7867)
- Frederik Marmé (ORCID: https://orcid.org/0000-0002-6591-3367)
- Jean‐François Baurain (ORCID: https://orcid.org/0000-0003-4876-4600)
- Paweł Blecharz (ORCID: https://orcid.org/0000-0001-5310-0054)
- Mariusz Bidziński (ORCID: https://orcid.org/0000-0003-4767-6369)
- Lukáš Rob (ORCID: https://orcid.org/0000-0003-3770-651X)
- Kristina Lindemann (ORCID: https://orcid.org/0000-0002-2162-0175)
- Roberto S Oliveri (ORCID: https://orcid.org/0009-0008-8833-4465)
- Linn Woelber (ORCID: https://orcid.org/0000-0002-9578-3049)
- Kaja C. G. Berg (ORCID: https://orcid.org/0000-0001-5509-0638)
- Josef Chovanec
- Michal Zikán (ORCID: https://orcid.org/0000-0001-5266-8895)
- Anders Rosholm
- Christian Dannecker (ORCID: https://orcid.org/0000-0003-2333-0769)
- Frédéric Forget
Institutions
- Oslo University Hospital (NO)
- Cliniques Universitaires Saint-Luc (BE)
- Universität Hamburg (DE)
- University of Augsburg (DE)
- University of Oslo (NO)
- Heidelberg University (DE)
- Ghent University Hospital (BE)
- University Hospital Heidelberg (DE)
- Fakultní nemocnice Bulovka (CZ)
- Medizinische Hochschule Hannover (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Masaryk Memorial Cancer Institute (CZ)
- The Maria Sklodowska-Curie National Research Institute of Oncology (PL)
- University Hospital Kralovske Vinohrady (CZ)
- University Medical Centre Mannheim (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1136/jitc-2024-010827
- Citations
- 9
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 12.19
Funders
- F. Hoffmann-La Roche
- Hvidovre Hospital