In Vitro and in Silico Binding Studies of Chromeno-Pyrimidine Derivatives With Biological Important Protein-Part III

In this study, in vitro and in silico interactions of bovine serum albumin with chromeno-pyrimidine derivatives (CP), 5-(7- bromo-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno-[2,3-d]pyrimidin-5-yl)pyrimidine2,4,6(1H,3H,5H)-tri-one (CP1) and 8,9-dihydroxy-2H-chromeno[2,3-d] pyrimidine <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$2,4(3 H)$</tex> dione (CP-2), are investigated. The high value of in vitro obtained binding constants are the result of good binding of the investigated compounds to BSA. Molecular docking results explain the interactions of BSA to the tested compounds and it is consistent with the experimentally obtained results.