Cerebral Venous Thrombosis in a Transgender Man Receiving Testosterone Therapy and Progestin Implant

We report a case of a transgender man receiving testosterone and progestin therapy for gender-affirming care who presented with a progressive unilateral headache and was ultimately diagnosed with cerebral venous thrombosis. We review available evidence regarding the risk for cerebral venous thrombosis among patients receiving testosterone and progestin therapy in the context of gender-affirming care and outline our approach to the management of this case.