Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3β/NRF2 Pathway
This study demonstrates that remimazolam activates the AKT/GSK-3β/NRF2 pathway, thereby attenuating oxidative stress and apoptosis to protect against brain I/R injury.
Authors
- Mingyue Duan
- Siyi Song
- Shi-Lei Wang (ORCID: https://orcid.org/0000-0002-5762-539X)
- Jia Liu (ORCID: https://orcid.org/0000-0001-6711-3841)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-3752-8365)
- Yang Zhao (ORCID: https://orcid.org/0000-0003-0276-4058)
- Ning Yu (ORCID: https://orcid.org/0000-0002-4580-0402)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/dddt.s478692
- Citations
- 19
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 15.31
Funders
- Qingdao University