The Synergic Effect of Zinc Oxide Nanoparticles and Coconut Oil as Antioxidant, and Their Effect on the Reproductive Systems of Female Rats

The purpose of this study was to detect the synergic effect of zinc oxide nanoparticles (ZnO-NPs and coconut oil effect as antioxidant, and there effect on the reproductive systems of female rats. The experiments included experimentally infected the animals with candida albicans Rats were infected with a 1 ml inoculum (3 × 109 yeast/ml) on day 0 and stressed immediately after the infection and during the following 2 days as single dose (3 ml) after dilution the main culture. After that the ZNO and coconut oil were using to know the effect of both on the reduction the oxidative effect of fungus infection. The doses of 5 mg/kg of ZnO, and 0.5 ml of coconut oil were administrated to infected Wister rats. Hormonal and oxidative, parameters were accessed after (30) days of experiment. The histopathological evaluations of tissues were also performed for uterus and ovary. The level of (LH, FSH, and progesterone) was observed to detect the effect of both treatments on the fertility level and oxidative markers. All the treated groups were comparable to control group at the end of the experiment. The results showed a significant decrease of hormones in infected female with Candeda albicans, while the level of these hormone begin to return to its normal value after ZNO and coconut oil treatment. Significant differences of oxidation marker were obtained in this study.