EHMT2‐mediated R‐loop formation promotes the malignant progression of prostate cancer via activating Aurora B
Euchromatic histone lysine methyltransferase 2 (EHMT2) is overexpressed in advanced prostate cancer, restraining catastrophic chromosomal instability (CIN) and enhancing cell fitness. EHMT2 functions via the centromeric R-loop-driven ATR-CHK1-Aurora B pathway to promote chromosomal stability. EHMT2 confers enzalutamide resistance via activating Aurora B. Cullin 3 (CUL3) promotes EHMT2 destabilisation via deubiquitination.
Authors
- Yuyang Zhang (ORCID: https://orcid.org/0009-0003-2906-4892)
- Xue Dong (ORCID: https://orcid.org/0000-0003-4790-8975)
- Xingliang Feng
- Mingqin Su
- Li Cui (ORCID: https://orcid.org/0000-0003-4982-3916)
- Xiansheng Zhang (ORCID: https://orcid.org/0000-0001-6003-5182)
- Yi‐Ming Chen (ORCID: https://orcid.org/0000-0001-7593-3065)
- Renfang Xu (ORCID: https://orcid.org/0000-0002-9880-5653)
- Wei Xia (ORCID: https://orcid.org/0000-0001-6835-0320)
Institutions
- Anhui Medical University (CN)
- Soochow University (CN)
- The First People's Hospital of Changzhou (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/ctm2.70164
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province