Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation
Disturbed flow activates the ubiquitin‒proteasome degradation pathway of MAPK6 in endothelial cells, which is contingent on the binding of the ubiquitin ligase TRIM21 to MAPK6. Endothelial MAPK6 has an advantageous impact on decelerating plaque progression. MAPK6 regulates endothelial inflammation via the EGR1/CXCL12 axis.
Authors
- Zhi‐Mei Wang
- S R Chen
- Chow‐Seng Kong (ORCID: https://orcid.org/0009-0007-3446-9228)
- Ai‐Qun Chen (ORCID: https://orcid.org/0000-0002-0933-7406)
- Wenying Zhou (ORCID: https://orcid.org/0000-0001-6481-2604)
- Guang‐Feng Zuo (ORCID: https://orcid.org/0000-0002-9589-6035)
- Longsheng Wang (ORCID: https://orcid.org/0009-0003-7525-0880)
- S Wang (ORCID: https://orcid.org/0000-0002-8175-7018)
- Junjie Zhang (ORCID: https://orcid.org/0000-0003-2710-8516)
- Feng Wang (ORCID: https://orcid.org/0000-0003-1089-3095)
- Yue Gu (ORCID: https://orcid.org/0000-0002-6633-675X)
- Xiaofei Gao (ORCID: https://orcid.org/0000-0001-7428-119X)
- Shuai Luo (ORCID: https://orcid.org/0009-0008-9586-8916)
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/ctm2.70168
- Citations
- 5
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Natural Science Foundation of China