Effects of Zoledronic Acid and Teriparatide on Bone Regeneration After Bone Grafting in Ovariectomized Rat

Purpose: Osteoporosis, a condition characterized by decreased bone density, increases susceptibility to fractures.This study aimed to evaluate the early and mid-term effects of zoledronic acid and teriparatide on bone regeneration in rats with osteoporosis.Materials and Methods: Osteoporosis was induced in rats through ovariectomy, after which animals were randomly divided into four groups: TPD_2, TPD_4, ZA_2, and ZA_4.Calvarial bone grafting was performed eight weeks after ovariectomy.All animals were sacrificed 2 or 4 weeks after zoledronic acid and teriparatide administration.The tibia and calvaria were harvested for analysis.Results: In the calvaria, the volume fraction of newly formed bone was significantly higher in the ZA_4 group compared to the ZA_2 and TPD_2 groups.The specific bone surface area of residual grafts was significantly lower in the TPD_4 group compared to the ZA_2 and ZA_4 groups.The percentage of newly formed bone in the calvaria was significantly higher in the TPD_2 group compared to the ZA_2 group. Conclusion:Teriparatide plays a role in bone formation during the early stages of bone grafting particularly when bone formation is inhibited.These findings suggest that teriparatide may enhance the success rate of bone transplantation and accelerate the healing process.