RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells
These promising findings suggest that SPP86 is a potential drug candidate for the treatment of melanoma, warranting further research and development.
Authors
- Hong Luan
- Haidong Liu (ORCID: https://orcid.org/0000-0002-3414-7524)
- Ming Xin (ORCID: https://orcid.org/0000-0002-5706-3390)
- Juan Zheng (ORCID: https://orcid.org/0000-0003-2253-9018)
- Kun Wang (ORCID: https://orcid.org/0000-0003-0864-089X)
- Yuli Zhang (ORCID: https://orcid.org/0000-0003-4640-1806)
Institutions
- Second Hospital of Shandong University (CN)
- Liaocheng People's Hospital (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/dddt.s473390
- Citations
- 2
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Natural Science Foundation of Shandong Province