Potential of Liposomal FTY720 for Bone Regeneration: Proliferative, Osteoinductive, Chemoattractive, and Angiogenic Properties Compared to Free Bioactive Lipid
The current results confirm the high potential of FTY720 bioactive lipid, especially in its liposomal form, that demonstrated substantial reduction of cytotoxicity and prolonged preservation of the lipids bioactivity (compared to the free lipid), for accelerated treatment of bone defects. Interestingly, the current studies prove the potential of FTY720, especially in its liposomal form, to promote reprogramming of L929 fibroblasts into osteoblasts, a novel finding deserving future exploitation.
Authors
- Foteini Gkartziou (ORCID: https://orcid.org/0000-0001-8605-9895)
- Antonia Marazioti (ORCID: https://orcid.org/0000-0002-1978-1121)
- Despoina Nektaria Metsiou (ORCID: https://orcid.org/0000-0002-4508-0249)
- Panagiota Mouzoura
- Sophia G. Antimisiaris (ORCID: https://orcid.org/0000-0002-2312-5848)
Institutions
- University of Peloponnese (GR)
- University of Patras (GR)
- FORTH Institute of Chemical Engineering Sciences (GR)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/ijn.s494512
- Citations
- 3
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- University of Patras
- European Commission
- Horizon 2020 Framework Programme