TAS2R38 genotype and CRS severity in children with cystic fibrosis
The findings highlight the role of <i>TAS2R38</i> as a potential genetic modifier influencing the severity of chronic rhinosinusitis in children with cystic fibrosis. The clinical implications include the potential development of T2R38-targeted topical therapies and the use of taste testing or genotyping to predict susceptibility to infection. In addition, these results may pave the way for novel, tailored therapeutic approaches in the era of precision medicine.
Authors
- Angela Sepe (ORCID: https://orcid.org/0000-0001-5708-4135)
- Antonella Tosco (ORCID: https://orcid.org/0000-0003-0470-6839)
- Elena Cantone (ORCID: https://orcid.org/0000-0002-7389-2033)
- Mario Brandon Russo (ORCID: https://orcid.org/0000-0002-9029-8191)
- Chiara Cimbalo (ORCID: https://orcid.org/0000-0003-3078-4662)
- Claudio Di Nola
- Rossella Negri (ORCID: https://orcid.org/0000-0002-7372-681X)
- Luigi Greco (ORCID: https://orcid.org/0000-0002-9443-5325)
- Giusi Grimaldi
- Paolo Pezzella
- Valeria Raia
- Alice Castaldo
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Heliyon
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.heliyon.2025.e41716
- Citations
- 3
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.39