Prognostic impact of depth of response and early tumour shrinkage in patients with <i>BRAF</i><sup><i>V600E</i></sup>-mutated metastatic colorectal cancer treated with targeted therapy
A DpR of at least 15% independently predicts PFS benefit in <i>BRAF</i> <sup><i>V600E</i></sup> mutated mCRC patients treated with second-line EC ± B.
Authors
- Massimiliano Salati (ORCID: https://orcid.org/0000-0002-5579-7454)
- Marco Maria Germani (ORCID: https://orcid.org/0000-0002-1036-5869)
- Rossana Intini (ORCID: https://orcid.org/0000-0001-8428-0721)
- Maria Alessandra Calegari (ORCID: https://orcid.org/0000-0001-6856-2593)
- Filippo Ghelardi (ORCID: https://orcid.org/0009-0001-1820-4402)
- Lisa Salvatore (ORCID: https://orcid.org/0000-0003-3864-0719)
- Guglielmo Vetere (ORCID: https://orcid.org/0000-0001-6943-2897)
- Alberto Puccini (ORCID: https://orcid.org/0000-0002-2492-4043)
- Mario Scartozzi (ORCID: https://orcid.org/0000-0001-5977-5546)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Alessandro Minelli (ORCID: https://orcid.org/0000-0003-3387-1489)
- Chiara Boccaccio (ORCID: https://orcid.org/0000-0003-1019-5983)
- Francesco Giulio Sullo (ORCID: https://orcid.org/0000-0002-6478-0638)
- Daniele Lavacchi
- Maria Bensi (ORCID: https://orcid.org/0000-0002-5647-0525)
- Filippo Pietrantonio (ORCID: https://orcid.org/0000-0002-8530-8420)
- Carlotta Antoniotti (ORCID: https://orcid.org/0000-0001-6881-3188)
- Chiara Cremolini (ORCID: https://orcid.org/0000-0002-0520-4841)
- Ada Taravella (ORCID: https://orcid.org/0009-0000-2153-3867)
- Laura Noto
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Pisa (IT)
- University of Modena and Reggio Emilia (IT)
- University of Cagliari (IT)
- Agostino Gemelli University Polyclinic (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Istituto Oncologico Veneto (IT)
- Ospedale San Paolo (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Policlinico Universitario di Catania (IT)
- Ospedale Policlinico San Martino (IT)
- Civita (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- Therapeutic Advances in Medical Oncology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1177/17588359241299975
- Citations
- 2
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Les Laboratories Pierre Fabre
- BeiGene
- Incyte
- Seagen
- European Commission
- Daiichi-Sankyo
- Astellas Pharma
- Associazione Italiana per la Ricerca sul Cancro
- Servier
- Ipsen