Noninvasive Detection of Alpha-Amylase in Saliva Using Screen-Printed Carbon Electrodes: A Promising Biomarker for Clinical Oral Diagnostics
A gold nanoparticle-modified screen-printed electrode (SPE) was developed to measure alpha-amylase quantitatively. Despite sensitivity to external interference, notably temperature, pH, and the duration of incubation, While the sensor showed sensitivity to external factors such as pH and temperature variations, it maintained a strong linear response, reinforcing its potential for reliable diagnostics with linear regression score <i>(R²</i> = 0.9513) across alpha-amylase concentrations of 100-500 units. This study underscores the sensor's effectiveness as a non-invasive tool for early detection using saliva as a biomarker, enhancing patient comfort and compliance. However, further research is needed for medical applications.
Authors
- Yuspian Nur (ORCID: https://orcid.org/0000-0002-8900-0810)
- Muhammad Yusuf (ORCID: https://orcid.org/0000-0003-1627-1553)
- Veni Takarini (ORCID: https://orcid.org/0000-0002-9673-0766)
- Sri Susilawati (ORCID: https://orcid.org/0000-0003-1004-2055)
- Dudi Aripin (ORCID: https://orcid.org/0000-0002-0669-1936)
- Maria Komariah (ORCID: https://orcid.org/0000-0003-1648-4882)
- Beenish Fatima Alam (ORCID: https://orcid.org/0000-0002-7668-706X)
- Abdul Rauf (ORCID: https://orcid.org/0000-0002-0047-7250)
- Faris Reviansyah (ORCID: https://orcid.org/0009-0007-5432-6849)
- Azzahra Delvyra Ristin
- Prisilia Sepirasari
- Fahmi Alim
Institutions
- Mulawarman University (ID)
- Padjadjaran University (ID)
Publication Details
- Journal
- Medical Devices Evidence and Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.2147/mder.s493383
- Citations
- 5
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Universitas Padjadjaran