Impact of LITAF on Mitophagy and Neuronal Damage in Epilepsy via MCL‐1 Ubiquitination
Our findings demonstrate that LITAF regulates MCL-1 ubiquitination, significantly impacting mitochondrial autophagy and contributing to neuronal damage in epilepsy. Targeting LITAF and its downstream mechanisms may offer a promising therapeutic strategy for managing epilepsy.
Authors
- Zhaofei Dong
- Hong Wu (ORCID: https://orcid.org/0000-0001-9142-499X)
- Linming Zhang
- Fuli Min
- Shui-Sheng Zhong
- Sai Zhang (ORCID: https://orcid.org/0000-0002-8028-4183)
- Ze Li
- Tao Zeng (ORCID: https://orcid.org/0000-0002-6185-1517)
Institutions
- Sun Yat-sen University (CN)
- Kunming Medical University (CN)
- Guangzhou First People's Hospital (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Zhujiang Hospital (CN)
- Guangdong 999 Brain Hospital (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
- Southern Medical University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1111/cns.70191
- Citations
- 4
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 5.42
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province