Inheritance of Imaging Parameters of Arrhythmic Risk in Mitral Valve Prolapse: A Pedigree Study
In the context of familial MVP, SCA/SCD is rarely observed in multiple generations and is not consistently linked to mitral annular disjunction. Instead, SCA may result from combination of abnormal valvular-myocardial mechanics and a substrate of increased mechanical/electrical dispersion. Family members with normal mitral valves also exhibit mildly abnormal global strain parameters, suggesting an underlying myopathy independent of MVP expression. Future studies are needed to determine whether SCA/SCD in MVP requires the concomitant presence of abnormal mechanics and a primary genetic myopathy.
Authors
- Robert A. Levine (ORCID: https://orcid.org/0000-0002-9484-8218)
- Lionel Tastet (ORCID: https://orcid.org/0000-0002-6374-5398)
- Zian H. Tseng (ORCID: https://orcid.org/0000-0001-5996-4099)
- Dwight Bibby
- Janet J. Tang (ORCID: https://orcid.org/0000-0001-8062-2536)
- Nelson B. Schiller (ORCID: https://orcid.org/0000-0001-5489-4378)
- Henry H. Hsia (ORCID: https://orcid.org/0000-0001-8187-9755)
- Luca Cristin (ORCID: https://orcid.org/0009-0003-2932-8659)
- Yasufumi Nagata (ORCID: https://orcid.org/0000-0001-5481-7524)
- Francesca N. Delling (ORCID: https://orcid.org/0000-0002-5224-4096)
- Satoshi Higuchi (ORCID: https://orcid.org/0000-0003-1644-3140)
- Rohit Jhawar
- Shalini Dixit
- Amy H. Rich
- Qizhi Fang
Institutions
- Massachusetts General Hospital (US)
- Hi-Z Technology (United States) (US)
Publication Details
- Journal
- Circulation Cardiovascular Imaging
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1161/circimaging.124.017051
- Citations
- 2
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78