Transition-metal-free C(sp<sup>3</sup>)–C(sp<sup>2</sup>) couplings with secondary alcohols and boronic acids <i>via</i> neighboring group activation

This study introduces a mild, transition-metal-free method for the C(sp 3 )-C(sp 2 ) cross-coupling of alkenyl boronic acids with secondary alcohols through neighboring group activation, enabling the efficient synthesis of valuable ortho -allylphenols.

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Publication Details

Journal
Organic Chemistry Frontiers
Published
2025-01-01
DOI
https://doi.org/10.1039/d4qo02061h
Primary Topic
Catalytic Cross-Coupling Reactions
Type
article
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article

Transition-metal-free C(sp3)–C(sp2) couplings with secondary alcohols and boronic acids via neighboring group activation

Changwen Hu, Yong Pan, Feng Wan, Xingxing Yang et al.
Organic Chemistry Frontiers
Catalytic Cross-Coupling Reactions
article

Transition-metal-free C(sp3)–C(sp2) couplings with secondary alcohols and boronic acids via neighboring group activation

Changwen Hu, Yong Pan, Feng Wan, Xingxing Yang, Cheng Ren, Hongliang Duan, Chengxi Li
article en

Abstract

This study introduces a mild, transition-metal-free method for the C(sp 3 )-C(sp 2 ) cross-coupling of alkenyl boronic acids with secondary alcohols through neighboring group activation, enabling the efficient synthesis of valuable ortho -allylphenols.

Organic Chemistry FrontiersVol. 12(6)
Zhejiang Lab (CN), Macao Polytechnic University (MO), Zhejiang University (CN)
Clean water and sanitation
Openalex Percentile: Top 100%
Catalytic Cross-Coupling Reactions
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