Plasma Microbial Cell-free DNA Sequencing for Diagnosis of Pediatric Lyme Disease
We conducted an exploratory study of plasma microbial cell-free DNA sequencing for the diagnosis of Lyme disease among pediatric patients. Low levels of Borrelia burgdorferi microbial cell-free DNA (<3-5 molecules per microliter) were observed in 6/9 serologically confirmed participants, including 4/5 with arthritis and 2/3 with multiple erythema migrans.
Authors
- Asim A. Ahmed (ORCID: https://orcid.org/0000-0003-1340-8825)
- Sivan Bercovici (ORCID: https://orcid.org/0000-0002-4310-4868)
- Shivkumar Venkatasubrahmanyam
- Desiree Hollemon (ORCID: https://orcid.org/0000-0003-4971-9334)
- Christy Beneri
- Andrew S Handel (ORCID: https://orcid.org/0000-0003-3544-4376)
- Carine Ho (ORCID: https://orcid.org/0000-0003-2034-9392)
- Qing Mao
Institutions
- Stony Brook School (US)
- Stony Brook Children's Hospital (US)
- Stony Brook University (US)
- Fresenius Kabi (Czechia) (CZ)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2024-12-31
- DOI
- https://doi.org/10.1097/inf.0000000000004707
- Citations
- 3
- Primary Topic
- Vector-borne infectious diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.55